The pathway of intrinsic apoptosis is different than that of extrinsic pathway, the former begins with intracellular specific signals like DNA damage or viral infections while the latter begins with extrinsic signal that involves natural killer or CD8-positive cytotoxic T lymphocytes in the immune system. (Elmore, 2007; Galluzzi, 2018; Lossi, 2022; Yanumula, 2021)
References
Elmore, S. (2007). Apoptosis: A review of programmed cell death. Toxicologic Pathology, 35(4), 495-516. https://doi.org/10.1080/01926230701320337
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Annicchiarico-Petruzzelli, M., Antonov, A. V., Arama, E., Baehrecke, E. H., Barlev, N. A., Bazan, N. G., Bernassola, F., Bertrand, M. J. M., Bianchi, K.,… Kroemer, G. (2018). Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death & Differentiation, 25(3), 486-541. https://doi.org/10.1038/s41418-017-0012-4
Lossi, L. (2022). The concept of intrinsic versus extrinsic apoptosis. Biochemical Journal, 479(3), 357-384. https://doi.org/10.1042/BCJ20210854
Yanumula, A., & Cusick, J. K. (2021). Biochemistry, extrinsic pathway of apoptosis. StatPearls Publishing.
